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US 11,229,621 B2Granted
Pharmaceutical compositions of dimethyl fumarate
AssigneeArbor Pharmaceuticals, LLC
InventorsSami Karaborni, Wei Chen, Suresh Kumar Manthati
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Abstract
Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
Claims7
A dosage form for treating multiple sclerosis, comprising:
- (a) a therapeutically effective amount of dimethyl fumarate in solid form;
- (b) one or more compounds of Formula (II):
- isomers thereof and salts of any of the foregoing, wherein:
- each of R5 and R7 is independently chosen from hydrogen and methyl;
- Y is chosen from O, S, NH and NR8;
- R6 is chosen from hydrogen, lower alkyl and aryl;
- R8 is chosen from lower alkyl;
- and
- wherein the one or more compounds of Formula (II) are present in a combined total amount of 0.001% to 3% by weight based on total weight of dimethyl fumarate;
- and
- (c) a pharmaceutically acceptable vehicle.
8 more elements
Dependencies are inferred from the claim text.