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US 11,229,617 B2Granted
Topical anti-inflammatory compositions
AssigneeAchelios Therapeutics, Inc.
InventorsServet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
Life of this patent
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Abstract
A topical composition includes a non-steroidal anti-inflammatory drug (NSAID) in an aqueous carrier system which contains a cationic galactomannan gum. The carrier system includes, in addition to water and the cationic galactomannan gum, a lactate ester of a C2 to C16 saturated aliphatic alcohol, a monoprotic arylalkanoic acid (pKa 3.8 to 5), a solubility enhancer, and a C2 to C8 saturated aliphatic alcohol.
Claims17
An aqueous, topical anti-inflammatory gel composition having a pH value in the range of about 3 to about 5.5, which comprises:
- a non-steroidal anti-inflammatory drug (NSAID) which is an arylalkanoic acid, a lactate ester of a C2 to C16 saturated aliphatic alcohol, a monoprotic organic acid having a pKa value in the range of about 3.8 to about 5, a C2 to C8 saturated aliphatic alcohol, a monoglyceride solubility enhancer, and a cationic guar gum;
- wherein lactate ester of a C2 to C16 saturated aliphatic alcohol is Lauryl lactate and the a C2 to C8 saturated aliphatic alcohol is a monohydric alcohol;
- wherein the arylalkanoic acid is present in an amount in the range of about 0.5 to about 7 percent by weight of the composition;
- and the cationic guar gum is present in an amount in the range of about 1 to about 5 percent by weight of the composition.
1 more element
Dependencies are inferred from the claim text.