Compositions including epinephrine microcrystals
AssigneeNova Southeastern University
InventorsMutasem Rawas-Qalaji, Ousama Rachid, Keith Simons, Estelle Simons
Life of this patent
Estimating the term…
Abstract
The invention provides compositions including epinephrine fine particles, including epinephrine nanoparticles or nanocrystals and epinephrine microparticles or microcrystals, and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine fine particles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required.
Claims12
A pharmaceutical composition formulated as a tablet for buccal or sublingual administration comprising approximately 10 mg to approximately 40 mg of stabilized epinephrine bitartrate microcrystals, the stabilized epinephrine bitartrate microcrystals having a spherical shape, the spherical shape formed when raw epinephrine bitartrate particles having a rectangular shape undergo a morphological change when reduced in size to form the stabilized epinephrine bitartrate microcrystals of the pharmaceutical composition.
A pharmaceutical composition formulated as a tablet for buccal or sublingual administration having an active ingredient consisting of 10 mg to 40 mg stabilized epinephrine bitartrate microcrystals, the stabilized epinephrine bitartrate microcrystals having a spherical shape, the spherical shape formed when raw epinephrine bitartrate particles undergo a morphological change when reduced in size to form the stabilized epinephrine bitartrate microcrystals of the pharmaceutical composition.
Dependencies are inferred from the claim text.