Parenteral formulations
AssigneeGW Research Limited
InventorsStephen Wright, Jitinder Wilkhu
Life of this patent
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Abstract
The present invention relates to parenteral cannabinoid formulations, and more particularly to cannabinoid containing intravenous (IV) formulations. Preferably the parenteral containing formulation comprises a cannabinoid; an isotonic agent; a surfactant; and one or more stability enhancers. Furthermore the cannabinoid may be selected from one or more of cannabichromene (CBC), cannabichromenic acid (CBCV), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabigerol (CBG), cannabigerolpropyl variant (CBGV), cannabicyclol (CBL), cannabinol (CBN), cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV) and tetrahydrocannabivarinic acid (THCVA).
Claims16
An aqueous parenteral formulation comprising:
- (i) about 0.3 mg/mL to about 50 mg/mL of a cannabinoid comprising cannabichromene (CBC), cannabichromenic acid (CBCV), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabigerol (CBG), cannabigerol propyl variant (CBGV), cannabicyclol (CBL), cannabinol (CBN), cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), tetrahydrocannabivarinic acid (THCVA), or combinations thereof;
- (ii) about 5 mg/mL to about 50 mg/mL of an isotonic agent comprising glucose, polyethylene glycol, or glycerol;
- (iii) about 5 mg/mL to about 500 mg/mL of a non-ionic surfactant comprising polyoxyethylene (20) sorbitan monooleate, macrogol 15 hydroxystearate, or polyoxamers;
- and
- (iv) about 0.1 mg/mL to about 10 mg/mL of one or more stability enhancers comprising ascorbic acid, monothioglycerol, cysteine HCl, glutathione, disodium EDTA, calcium disodium EDTA, or combinations thereof;
- wherein the formulation has an osmolality of from 100-500 mOsMol/Kg;
- and
- wherein the formulation has a shelf-life of at least about 12 months.
Dependencies are inferred from the claim text.