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US 11,229,604 B2Granted
Microspheres containing therapeutic agents and related methods of use
AssigneeBiosphere Medical, Inc.
InventorsPhilippe Reb, Meriadeg Thomas
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Abstract
Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.
Claims18
Microspheres suitable for use in therapeutic embolization, comprising:
- a biocompatible, polymeric material comprising a copolymer comprising:
- one or more acrylamide monomers;
- a monomer comprising an alkyne functional group, wherein the monomer comprising an alkyne functional group comprises a monomer of formula I:
- or formula II:
- wherein X is NR1, wherein R1 is selected from H, CH3, or C1-C6 alkyl,
- wherein R is selected from H, CH3, or C1-C6 alkyl, and
- wherein n can be any integer from 1 to 20;
- and
- a cyclodextrin or a derivative thereof grafted to the copolymer;
- and
- a therapeutic agent,
- wherein the copolymer comprises between about 10% and about 90% by weight of the monomers, and between about 10% and about 90% by weight of the cyclodextrin, wherein the polymeric material is crosslinked and the microspheres are non-resorbable.
9 more elements
Microspheres suitable for use in therapeutic embolization, comprising:
- a biocompatible, polymeric material comprising a copolymer comprising:
- one or more acrylamide monomers;
- a monomer comprising an alkyne functional group, wherein the monomer comprising an alkyne functional group comprises a monomer of formula I:
- or formula II:
- wherein X is NR1, wherein R1 is selected from H, CH3, or C1-C6 alkyl,
- wherein R is selected from H, CH3, or C1-C6 alkyl, and
- wherein n can be any integer from 1 to 20;
- and
- a cyclodextrin or a derivative thereof grafted to the copolymer;
- and
- a therapeutic agent,
- wherein the copolymer comprises between about 10% and about 90% by weight of the monomers, and between about 10% and about 90% by weight of the cyclodextrin, and wherein at least a portion of each microsphere is water insoluble such that the microsphere retains a substantially spherical shape after placement in a region of a patient's vasculature body, wherein the polymeric material is crosslinked and the microspheres are non-resorbable such that the microspheres, when disposed in the region, are configured to decrease blood flow across the region by more than 80% after degradation of the cyclodextrin or derivative thereof.
9 more elements
Dependencies are inferred from the claim text.