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AssigneesWestern University of Health Sciences, Tesorx Pharma, LLC
InventorsGuru V. Betageri, Natarajan Venkatesan, Michael G. Oefelein, Ramachandran Thirucote, Nitin Kumar Swarnakar, Teresa Hong
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Compositions and methods for making and using proliposomal and liposomal formulations of chemotherapeutic agents are disclosed. The proliposomal and liposomal formulations of chemotherapeutics, as well as medicaments and dosage forms that include such formulations, can be used with treatment regimens for bladder cancer and urothelial cancer. Hence, the formulations, medicaments, and dosage forms of the invention are suitable to treat bladder cancers by intravesical administration and to treat urothelial cancers. The formulations according to the invention include (a) a taxane (e.g., paclitaxel, docetaxel) or cisplatin, (b) a first phospholipid, dipalmitoyl phosphatidylcholine (DMPC), and (c) a second phospholipid, dimyrsityl phosphatidyl glycerol sodium (DMPG). The proliposomal formulations form liposomes upon contact with an aqueous vehicle.
A proliposomal powder dispersion formulated for intravesical administration, consisting of
A method of preparing a liposomal paclitaxel formulation for intravesical administration, comprising the steps of:
Dependencies are inferred from the claim text.