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US 11,229,591 B2Granted
Methods for synthesizing zinc-lysine-chloride complex
AssigneeColgate-Palmolive Company
InventorsStanislav Jaracz, Long Pan
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Abstract
Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride with a slight molar excess of amino acid hydrohalide, as well as oral care compositions comprising said complexes made according to said method.
Claims8
A method of making a zinc-amino acid-halide complex, comprising the step of reacting zinc oxide with an amino acid hydrohalide in aqueous solvent with a slight excess of the amino acid hydrohalide;
- wherein the zinc-amino acid-halide complex has the structural formula [Zn(C6H14N2O2)2Cl]+Cl−, and wherein the method comprises reacting zinc oxide with 2.4-2.6 molar equivalents of lysine hydrochloride at room temperature, and wherein the solvent consists of water, and wherein the method comprises adding the zinc oxide to the water, followed by the addition of the lysine hydrochloride;
- and wherein the method comprises isolating the product as a crystalline solid by adding ethanol to the reaction mixture to form crystals free of unreacted lysine.
Dependencies are inferred from the claim text.