Pixel array medical systems, devices and methods

A system, comprising:

• a handpiece configured to removably couple to a proximal end of a housing, wherein the handpiece includes a drive system;
• a scalpet assembly configured to removeably couple to a distal end of the housing and the drive system, wherein the scalpet assembly includes a scalpet array comprising at least one scalpet configured for rotation using force delivered from the drive system, wherein the scalpet array is configured to harvest dermal plugs from a donor site via fractional resection;
• a collection chamber coupled to the housing and configured to collect the plurality of dermal plugs generated by the scalpet assembly, wherein the collection chamber is further housing formation of an injectable filler by mincing and mixing the dermal plugs with a carrier, wherein the injectable filler is configured for bulk fill including at least one of biomechanical bulk fill and reconstructive bulk fill, wherein the collection chamber includes a loading port;
• and
• a cannular syringe configured to mate with the loading port to receive the injectable filler, and to deliver the injectable filler for the bulk fill.