Hydraulic displacement and removal of thrombus clots, and catheters for performing hydraulic displacement
AssigneeMIVI Neuroscience, Inc.
InventorMatthew F. Ogle
Life of this patent
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Abstract
Clot removal from a patient's vessel, such as an artery, are described using aspiration and hydraulic forces supporting the removal process. Hydraulic forces can be generated by occluding the vessel distal to the clot and delivering liquid between the clot and the occlusive device. The aspiration catheter is positioned proximal to the clot. Catheters designed to facilitate the delivery of hydraulic forces can be based on single lumen designs or dual lumen designs. The catheters may have a fixed internal wire, or in some embodiments the catheters can ride over a wire with a valve/seal positioned to restrict flow into or out from the guide lumen such that the guide lumen can further function for balloon inflation and/or for infusion of liquid.
Claims18
A method for removing a clot from a patient's cerebral arteries, the method comprising:
- delivering a single lumen microcatheter over a guidewire positioned through the clot to place the distal end of the microcatheter at a distal position in a cerebral artery relative to the clot, wherein the microcatheter has an outer diameter at a distal portion from 1 Fr to 3 Fr;
- delivering a catheter with an occluding element through the microcatheter to place an un-deployed occluding element distal to the clot, wherein the occluding element comprises a balloon;
- occluding the cerebral artery with the occluding element distal to the clot wherein the cerebral artery is occluded prior to infusion of liquid;
- applying a hydraulic force by providing a first higher pressure to a distal end of the clot by infusing liquid between the clot and the occluding element from ports exclusively positioned distal to the clot to generate hydraulic forces on the distal end of the clot and providing a second lower pressure to a proximal end of the clot by aspirating liquid from the cerebral artery proximal to the clot with at least some temporal overlap of infusing and aspirating to push the clot in a distal to proximal direction relative to the microcatheter, wherein the lower pressure is applied with an aspiration catheter having a distal aspiration opening within cerebral arteries, and wherein the hydraulic force is directed towards the clot without prior mechanical fragmentation.
A method for removing a clot from a patient's cerebral artery, the method comprising:
- delivering a catheter with an occluding element through a microcatheter with a distal opening distal to the clot to place an un-deployed occluding element distal to the clot in the cerebral artery;
- occluding the cerebral artery with the occluding element distal to the clot;
- creating a differential pressure across the clot by infusing liquid between the clot and the occluding element from ports exclusively positioned distal to the clot to generate hydraulic forces on a distal end of the clot and aspirating liquid from the cerebral artery proximal to the clot with at least some temporal overlap of infusing and aspirating to push the clot in a distal to proximal direction, wherein a distal end of an aspiration catheter is within the cerebral arteries, and wherein the hydraulic force is directed towards the clot without prior mechanical fragmentation,
- wherein aspiration for aspirating liquid is provided by the aspiration catheter delivered over the catheter with the occluding element, wherein the occluding element comprises a balloon and wherein the microcatheter is located over the catheter with the occluding element with its distal opening distal to the clot and from about 0.25 cc to about 25 cc of infusion liquid is delivered from the microcatheter.
Dependencies are inferred from the claim text.