Discrimination of calculi and tissues with molecular chemical imaging

An imaging system for discriminating a calculus from surrounding tissue, comprising:

• an illumination source configured to illuminate the calculus and surrounding tissue with one or more of a first plurality of illuminating photons having a first wavelength to generate a first plurality of interacted photons and a second plurality of illuminating photons having a second wavelength to generate a second plurality of interacted photons, wherein the first wavelength corresponds to a background and the second wavelength corresponds to the calculus;
• one or more detectors configured to detect the first plurality of interacted photons and the second plurality of interacted photons to generate a first image data set corresponding to the first plurality of interacted photons and a second image data set corresponding to the second plurality of interacted photons, wherein the first image data set and the second image data set each comprise hyperspectral data;
• and
• a processor that processes the first image data set and the second image data set and generates, using a multivariate algorithm, information related to a location of the calculus with respect to surrounding tissue based on the first image data set and the second image data set.

A method of discriminating a calculus from surrounding tissue, comprising:

• generating illuminating photons;
• filtering a first plurality of illuminating photons and generate a first plurality of filtered photons comprising first-multi-passband wavelengths and a second plurality of filtered photons comprising second multi-passband wavelengths, wherein the first multi-passband wavelengths correspond to a background and the second multi-passband wavelengths correspond to the calculus, wherein a sample is illuminated with the first plurality of filtered photons to generate a first plurality of interacted photons and a second plurality of interacted photons;
• and
• detecting the first plurality of interacted photons and the second plurality of interacted photons and generate a first image data set corresponding to the first plurality of interacted photons and a second image data set corresponding to the second plurality of interacted photons, wherein the first image data set and the second image data set each comprise hyperspectral data;
• and
• processing the first image data set and the second image data set and generating, using a multivariate algorithm, information related to a location of the calculus with respect to surrounding tissue based on the first image data set and the second image data set.

A method of discriminating a calculus from surrounding tissue, comprising:

• illuminating the calculus and surrounding tissue to thereby generate interacted photons;
• filtering one or more of a first plurality of the interacted photons and transmitting first multi-passband wavelengths and filtering a second plurality of interacted photons and transmitting second multi-passband wavelengths, wherein the first multi-passband wavelengths correspond to a background and the second multi-passband wavelengths correspond to the calculus;
• detecting the first multi-passband wavelengths and the second multi-passband wavelengths and generating a first image data set corresponding to the first passband wavelength and a second image data set corresponding to the second passband wavelength, wherein the first image data set and the second image data set each comprise hyperspectral data, and
• processing the first image data set and the second image data set and generating, using a multivariate algorithm, information related to a location of the calculus with respect to surrounding tissue based on the first image data set and the second image data set.

A method for discriminating a calculus from surrounding tissue, comprising:

• illuminating the calculus and surrounding tissue with one or more of a first plurality of illuminating photons having a first wavelength to generate a first plurality of interacted photons and a second plurality of illuminating photons having a second wavelength to generate a second plurality of interacted photons, wherein the first wavelength corresponds to a background and the second wavelength corresponds to the calculus;
• detecting the first plurality of interacted photons and the second plurality of interacted photons to generate a first image data set corresponding to the first plurality of interacted photons and a second image data set corresponding to the second plurality of interacted photons, wherein the first image data set and the second image data set each comprise hyperspectral data;
• and
• processing the first image data set and the second image data set and generating, using a multivariate algorithm, information related to a location of the calculus with respect to surrounding tissue based on the first image data set and the second image data set.