The present disclosure pertains to a system configured to output an indicator representative of effects of stimulation provided to a subject during a sleep session. The indicator is determined based on a combination of the effect of stimulation on sleep restoration, stimulation quality, sleep architecture factors, and/or other information. The indicator is determined using age matched reference information on deep sleep duration and EEG slow wave activity. The contribution to the indicator associated with sleep architecture factors is determined based on age matched reference information including sleep onset latency, wake after sleep onset, total sleep time, micro-arousal count, sleep stage(s) prior to awakening, and/or other information.
Drawings
Claims14
A system configured to output an indicator representative of effects of stimulation provided to a subject during a sleep session, the system comprising:
one or more stimulators configured to provide the stimulation to the subject during the sleep session;
one or more sensors configured to generate output signals conveying information related to brain activity in the subject during the sleep session;
and
one or more hardware processors operatively communicating with the one or more stimulators and the one or more sensors, the one or more hardware processors configured by machine-readable instructions to:
determine, based on the output signals and the stimulation provided to the subject:
a slow wave activity metric indicative of a cumulative amount of slow wave activity in the subject during the sleep session, the slow wave activity metric determined based on a cumulative slow wave activity factor and a non-rapid eye movement (NREM) duration factor;
a stimulation quality metric indicative how well the stimulation enhances slow wave activity in the subject during the sleep session, the stimulation quality metric determined based on one or both of a number of stimulations delivered to the subject during the sleep session and a number of stimulations at a specific intensity delivered to the subject during the sleep session;
and
a sleep architecture metric indicative of a sleep quality for the subject during the sleep session;
combine the slow wave activity metric, the stimulation quality metric, and the sleep architecture metric to determine the indicator;
and
output the indicator for display to the subject.
9 more elements
A system for outputting an indicator representative of effects of stimulation provided to a subject during a sleep session, the system comprising:
means for providing the stimulation to the subject during the sleep session;
means for generating output signals conveying information related to brain activity in the subject during the sleep session;
means for determining, based on the output signals and the stimulation provided to the subject:
a slow wave activity metric indicative of a cumulative amount of slow wave activity in the subject during the sleep session, the slow wave activity metric determined based on a cumulative slow wave activity factor and a non-rapid eye movement (NREM) duration factor;
a stimulation quality metric indicative of how well the stimulation enhances slow wave activity in the subject during the sleep session, the stimulation quality metric determined based on one or both of a number of stimulations delivered to the subject during the sleep session and a number of stimulations at a specific intensity delivered to the subject during the sleep session;
and
a sleep architecture metric indicative of a sleep quality for the subject during the sleep session, the sleep architecture metric determined based on one or more of a sleep onset latency value for the subject, a wake after sleep onset value for the subject, a total sleep time during the sleep session, or a number of arousals during the sleep session;
means for combining the slow wave activity metric, the stimulation quality metric, and the sleep architecture metric to determine the indicator;
and
means for outputting the indicator for display to the subject.
16/470,791Filed 21 Dec 2017 · us provisional application
Priority
22 Dec 2016
Published
US 2019/0343455 A114 Nov 2019
Granted
25 Jan 2022
Term ends
4 Aug 2038Estimated · howhide20 years from earliest known nonprovisional domestic filing plus recorded patent term adjustment, including 226 days of adjustment. Maintenance-fee lapses, terminal disclaimers and statutory extensions have not been checked. The continuity chain may be incomplete; this is not an enforceability determination.
#The present disclosure pertains to a system and method for outputting an indicator representative of effects of stimulation provided to a subject during a sleep session.
#Systems for monitoring sleep are known. The restorative value of sleep can be increased by delivering appropriately timed auditory stimulation during deep sleep to enhance sleep slow waves. Typically, systems for monitoring sleep do not automatically generate an output that informs a user of the benefits of stimulation provided during a sleep session. The present disclosure overcomes deficiencies in prior art systems.
#Accordingly, one or more aspects of the present disclosure relate to a system configured to output an indicator representative of effects of stimulation provided to a subject during a sleep session. The system comprises one or more stimulators, one or more sensors, one or more hardware processors, and/or other components. The one or more stimulators are configured to provide the stimulation to the subject during the sleep session. The one or more sensors are configured to generate output signals conveying information related to brain activity in the subject during the sleep session. The one or more hardware processors operatively communicate with the one or more stimulators and the one or more sensors. The one or more hardware processors are configured by machine-readable instructions to determine, based on the output signals and the stimulation provided to the subject: a slow wave activity metric indicative of a cumulative amount of slow wave activity in the subject during the sleep session; a stimulation quality metric indicative how well the stimulation enhances slow wave activity in the subject during the sleep session; and a sleep architecture metric indicative of a sleep quality for the subject during the sleep session. The one or more hardware processors are configured to combine the slow wave activity metric, the stimulation quality metric, and the sleep architecture metric to determine the indicator; and output the indicator for display to the subject.
Brief description of the drawings18 figures
#FIG. 1 illustrates a system configured to output an indicator representative of effects of stimulation provided to a subject during a sleep session.
#FIG. 2 illustrates examples of the operations performed by a therapy component of the system.
#FIG. 3 illustrates correlation between automatically determined and manually determined cumulative slow wave activity in the subject.
Detailed description10,990 words
#As used herein, the singular form of “a”, “an”, and “the” include plural references unless the context clearly dictates otherwise. As used herein, the statement that two or more parts or components are “coupled” shall mean that the parts are joined or operate together either directly or indirectly, i.e., through one or more intermediate parts or components, so long as a link occurs. As used herein, “directly coupled” means that two elements are directly in contact with each other. As used herein, “fixedly coupled” or “fixed” means that two components are coupled so as to move as one while maintaining a constant orientation relative to each other.
#As used herein, the word “unitary” means a component is created as a single piece or unit. That is, a component that includes pieces that are created separately and then coupled together as a unit is not a “unitary” component or body. As employed herein, the statement that two or more parts or components “engage” one another shall mean that the parts exert a force against one another either directly or through one or more intermediate parts or components. As employed herein, the term “number” shall mean one or an integer greater than one (i.e., a plurality).
#Directional phrases used herein, such as, for example and without limitation, top, bottom, left, right, upper, lower, front, back, and derivatives thereof, relate to the orientation of the elements shown in the drawings and are not limiting upon the claims unless expressly recited therein.