Antioxidant-enriched multivitamin composition and methods of use

A method of reducing the risk of pulmonary exacerbation in a subject suffering from cystic fibrosis, the method comprising administering to the subject an oral dosage form of a multivitamin consisting of:

• about 18,167 IU of a combination of vitamin A and a precursor of vitamin A, comprising about 8% retinyl palmitate and about 92% beta-carotene;
• about 75 mg vitamin C;
• about 3,000 IU vitamin D;
• about 150 IU vitamin E, wherein the vitamin E comprises a combination of about 80 mg mixed tocopherols and about 200 mg d-α-tocopherol polyethylene glycol 1000 succinate (TPGS);
• about 1 mg vitamin K;
• about 1.5 mg thiamin;
• about 1.7 mg riboflavin;
• about 10 mg niacin;
• about 1.9 mg vitamin B6;
• about 200 mcg folic acid;
• about 12 mcg vitamin B12;
• about 100 mcg biotin;
• about 12 mg pantothenic acid;
• about 10 mg zinc;
• about 75 mcg selenium;
• about 10 mg coenzyme Q10;
• about 5 mg lutein;
• about 1 mg lycopene;
• and
• about 0.75 mg zeaxanthin,
• wherein the multivitamin is administered twice daily for a period of at least 8 weeks.