N-acyldipeptide derivatives and their uses
AssigneeNeostrata Company, Inc.
InventorsRuey J. Yu, Eugene J. Van Scott
Life of this patent
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Abstract
Methods of treating aging related skin changes and of increasing skin thickness with topical administration of N-acyldipeptide derivatives are described. Compositions comprising N-acyldipeptide derivatives, are therapeutically effective for increasing skin thickness, and for treating extrinsic and intrinsic aging and aging related skin changes, such as fine lines, wrinkles, photoaging, hyperpigmentation, laxity, age spots, lentigines, mottled skin, and cellulite.
Claims19
A composition comprising gluconolactone and a therapeutically effective amount of a dipeptide derivative of formula (I):
- R1-AAB-AAC-R2 Formula (I)
- or an isomer or salt thereof, and optionally a pharmaceutically or cosmetically acceptable carrier, wherein R1 is an acyl radical having up to 9 carbon atoms;
- AAB is Tyr and AAC is Tyr, or AAB is Val and AAC is Ala;
- R2 is OR3, NHR4, or NHNHR5;
- R3 is H, an alkyl, aralkyl, or aryl radical having up to 19 carbon atoms;
- and R4 or R5 is independently H, OH, an alkyl, aralkyl, or aryl radical having up to 19 carbon atoms.
A method of treating aging related skin changes or changes associated with intrinsic or extrinsic aging, or of increasing skin thickness in a subject in need thereof, the method comprising topically administering to skin of the subject a composition comprising gluconolactone and a therapeutically effective amount of N—Ac-Val-Ala-NH2, or an isomer or salt thereof, and optionally a pharmaceutically or cosmetically acceptable carrier.
Dependencies are inferred from the claim text.