Bacterial strain clostridium histolyticum and methods of use thereof
AssigneeMB Pharma s.r.o.
InventorsMarek Mosa, Martin Benesik
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Abstract
Bacterial strain Clostridium histolyticum was deposited in CCM (Czech Collection of Microorganisms at Masaryk University, Faculty of Science) under No. CCM 8656. This strain produces proteolytic enzymes including collagenase, elastinase, neutral proteases and clostripain under anaerobic conditions at a temperature from 25° C. to 45° C. The strain is used for the production of a mixture of two collagenases, col 1 and col 2, with molecular weight 116 kDa and 126 kDa, and possibly clostripain. The mixture of the above-mentioned collagenases and possibly clostripain obtained from the above-mentioned strain is used for the isolation of Langerhans islets.
Claims5
A bacterial strain Clostridium histolyticum deposited under deposit number CCM 8656, wherein said bacterial strain produces proteolytic enzymes comprising collagenase, elastinase, neutral proteases and clostripain under anaerobic conditions at a temperature from 25° C. to 45° C.
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