Nitric oxide-releasing antibiotics, methods of making, and methods of use
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorsHitesh Handa, Sean P. Hopkins, Priyadarshini Singha, Christina Danielle Workman
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Abstract
The present disclosure provides for modified antibiotic compounds, methods of making modified antibiotic compounds, methods of use, products including modified antibiotic compounds, and the like. The modified antibiotic compound comprises a nitric oxide release agent covalently attached to an antibiotic molecule, such as S-nitroso-N-acetylpenicillamine covalently attached to ampicillin.
Claims20
A modified antibiotic compound comprising a nitric oxide release agent covalently attached to an antibiotic molecule, wherein the antibiotic molecule is ampicillin, vancomycin, gentamicin, or cephalexin.
A method of making a modified antibiotic compound, comprising:
- covalently attaching a nitric oxide release agent to an antibiotic molecule, wherein the attachment is formed by mixing the nitric oxide release agent and the antibiotic molecule in a solvent to form a mixture, and nitrosating the mixture.
A product with antimicrobial properties, comprising a polymer material and a modified antibiotic compound, where the modified antibiotic compound comprises a nitric oxide release agent covalently attached to an antibiotic molecule.
Dependencies are inferred from the claim text.