Compounds and compositions for intracellular delivery of therapeutic agents

A compound of Formula (I):

• or its N-oxide,
• or a salt thereof, wherein
• l is selected from 1, 2, 3, 4, and 5;
• m is selected from 5, 6, 7, 8, and 9;
• n is selected from 1, 2, 3, 4, and 5;
• M1 is a bond or M′;
• R2 and R3 are both C1-14 alkyl or C2-14 alkenyl;
• M and M′ are independently selected from —C(O)O—, —OC(O)—, —OC(O)-M″-C(O)O—, —C(O)N(R′)—, —C(O)N(H)—, —N(R′)C(O)—, —N(H)C(O)—, —C(O)—, —C(S)—, —C(S)S—, —SC(S)—, —CH(OH)—, —P(O)(OR′)O—, —P(O)(OH)O—, —S(O)2—, —S—S—, an aryl group, and a heteroaryl group, in which M″ is a bond, C1-13 alkyl or C2-13 alkenyl;
• R10 is selected from the group consisting of alkylamino and dialkylamino;
• and
• R′ is a linear alkyl.