Antibacterial and protective bacteriophage formulations and methods for making and using them
AssigneeSan Diego State University (SDSU) Foundation
InventorsForest Rohwer, Jeremy J. Barr
Life of this patent
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Abstract
In alternative embodiments, provided are compositions comprising chemically or structurally modified bacteriophages of the genus Caudovirales having an exterior or outer surface comprising at least one heterologous carbohydrate binding domain (CBD) comprising a lectin or a plurality of additional homologous CBDs, or more CBDs than found on a comparable wild type (WT) bacteriophage.
Claims18
A genetically engineered bacteriophage of the genus Caudovirales, wherein the genetically engineered bacteriophage genome is altered such that after reproduction in a host cell, or in an in vitro system, the exterior or outer surface of the genetically engineered bacteriophage expresses or displays:
- (a) on a tailspike protein at least one non-bacteriophage carbohydrate binding domain (CBD) comprising a lectin;
- (b) at least one heterologous bacteriophage Ig-like CBD;
- or
- (c) a combination of (a) and (b).
A genetically engineered bacteriophage of the genus Caudovirales, wherein the genetically engineered bacteriophage genome is altered such that after reproduction in a host cell, or in an in vitro system, the exterior or outer surface of the genetically engineered bacteriophage expresses or displays:
- (a) at least one non-bacteriophage carbohydrate binding domain (CBD) comprising a C-type lectin;
- (b) at least one heterologous bacteriophage Ig-like CBD;
- or
- (c) a combination of (a) and (b).
Dependencies are inferred from the claim text.