US 11,214,625 B2 · Application of PCSK9 inhibitors in the preparation of drugs for the treatment of inflammatory immune diseases

Abstract

The invention belongs to the biopharmaceutical. It involves the role and mechanism of PCSK9 in inflammatory immune diseases, and the application of PCSK9 inhibitors to the preparation of drugs for the treatment of inflammatory immune diseases mediated by T cells. In particular, it involves the use of PCSK9 monoclonal antibody, PCSK9 interference RNA and PCSK9 small molecule inhibitors for treating psoriasis, atopic dermatitis, or urticaria. The invention uses psoriasis as an embodiment for the study of inflammatory and immune diseases. It is found that PCSK9 plays an important role in the treatment of inflammatory immune diseases. The PCSK9 monoclonal antibody, PCSK9 interference RNA, and PCSK9 small molecule inhibitor can be further developed for treating inflammatory immune-diseases, such as psoriasis with fewer adverse reactions, at low cost, and with good efficacy.

Claims19

Dependent claims

A method of treating an inflammatory immune disease by administration of a therapeutically effective amount of a proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor selected from the group consisting of:

to a human in need thereof, wherein the inflammatory immune disease is selected from the group consisting of psoriasis, psoriatic arthritis, eczema, atopic dermatitis, urticaria, glucocorticoid dependent dermatitis, rheumatoid arthritis, scleroderma, diabetes, chronic liver disease, and lymphoma.

Dependencies are inferred from the claim text.

Facts

Application

15/965,907Filed 28 Apr 2018 · continuation in part

Priority

CN 201510728438.629 Oct 2015

Published

US 2018/0312607 A11 Nov 2018

Granted

4 Jan 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification19 codes

C07K 16/40
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against enzymes
A61K 31/437
Ortho- or peri-condensed with heterocyclic ring systems: the heterocyclic ring system containing a five-membered ring having nitrogen as a ring…
A61K 31/4743
Ortho- or peri-condensed with heterocyclic ring systems: condensed with ring systems having sulfur as a ring hetero atom
A61P 17/06
Drugs for dermatological disorders: antipsoriatics

Application of PCSK9 inhibitors in the preparation of drugs for the treatment of inflammatory immune diseases

Life of this patent

Application of PCSK9 inhibitors in the preparation of drugs for the treatment of inflammatory immune diseases

Life of this patent

Abstract

Claims19