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US 11,214,540 B2Granted
Compositions for treating neurodegenerative diseases
AssigneeCognition Therapeutics, Inc.
InventorsGilbert M. Rishton, Gary C. Look, Susan M. Catalano
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to novel compounds, and pharmaceutical compositions thereof, useful for treating for treating neurodegenerative diseases, including Alzheimer's disease and cognitive decline. Methods for inhibiting synapse number decline or membrane trafficking abnormalities associated with exposure of a neuronal cell to Abeta species are also disclosed. Representative members of these compounds include:
Claims8
A compound of Formula I or pharmaceutically acceptable salt thereof:
- wherein:
- each of Ra, Rb, Rc, Rd and Re is independently selected from the group consisting of, H, hydroxyl, halo, alkyl, alkoxy, CF3, SO2CH3, and morpholino;
- R1 is selected from the group consisting of hydrogen, alkyl, phenyl, or —CH═C(CH3)2;
- and
- R2 is an optionally substituted cyclic amino group;
- selected from the groups consisting of:
3 more elements
Dependencies are inferred from the claim text.