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US 11,213,612 B2Granted
Hybrid scaffold suitable for regenerating animal tissues and process for producing the scaffold
AssigneeDialybrid S.R.L.
InventorsValentina Ilaria Maria Catto, Sebastiao Nicolau Dentinho Van Uden, Francesco Giovanni Greco, Davide Meroni, Stefania Adele Riboldi
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Abstract
A hybrid scaffold is disclosed which is made of materials that define peripheral layers designed to interface with the tissues in the implant site and one or more intermediate layers. The materials are combined to give the scaffold mechanical properties suitable for withstanding the stresses of the implant site. The materials are fibroin for the peripheral layers and polyurethane combined with fibroin for each intermediate layer.
Claims18
A hybrid scaffold suitable for regenerating animal tissues comprising:
- peripheral layers made of a material suitable for interfacing with the tissues at the implant site and integrating with the host body cells;
- one or more intermediate layers made of combined materials which together are suitable for giving the scaffold mechanical properties suited to withstand the typical stresses in the implantation site and for generating stable coalescence between the layers,
- the materials being:
- fibroin for the peripheral layers,
- a blend of polyurethane and fibroin for each intermediate layer wherein the blend of each intermediate layer comprises electrospun fibroin and electrospun polyurethane, and whereby the blend inhibits delamination or detachment of the fibroin in the peripheral layers.
2 more elements
Dependencies are inferred from the claim text.