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US 11,208,500 B2Granted
Manufacturing process for cyclodextrin derivatives
AssigneeCyDex Pharmaceuticals, Inc.
InventorsVincent D. Antle, Jose R. Matos
Life of this patent
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Abstract
A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.
Claims31
A process for preparing a sulfoalkylether β-cyclodextrin, the process comprising:
- mixing a 3-cyclodextrin starting material with an alkalinizing agent batch-wise in a first reservoir to form a first starting material supply;
- providing an alkyl sultone in a second reservoir to form a second starting material supply;
- and
- combining and continuously or semi-continuously flowing the first and second starting material supplies through a flow-through reactor to form a raw product comprising the sulfoalkylether β-cyclodextrin;
- and
- wherein the first starting material supply and the second starting material supply have a residence time in the flow-through reactor of 0.5 seconds to 4 hours.
3 more elements
Dependencies are inferred from the claim text.