DNA antibody constructs and method of using same
AssigneesThe Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
InventorsDavid Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
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Abstract
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
Claims14
A nucleic acid molecule encoding a synthetic antibody comprising one or more nucleic acid sequences selected from the group consisting of:
- a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 67;
- a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 69;
- a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 71;
- a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 73;
- a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 75;
- a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 77;
- and
- a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 65.
A nucleic acid molecule encoding a synthetic antibody comprising one or more nucleic acid sequences selected from the group consisting of:
- a nucleic acid sequence encoding an amino acid sequence having at least 90% identity to SEQ ID NO:
- 68;
- a nucleic acid sequence encoding an amino acid sequence having at least 90% identity to SEQ ID NO:
- 70;
- a nucleic acid sequence encoding an amino acid sequence having at least 90% identity to SEQ ID NO:
- 72;
- a nucleic acid sequence encoding an amino acid sequence having at least 90% identity to SEQ ID NO:
- 74;
- a nucleic acid sequence encoding an amino acid sequence having at least 90% identity to SEQ ID NO:
- 76;
- a nucleic acid sequence encoding an amino acid sequence having at least 90% identity to SEQ ID NO:
- 78;
- and
- a nucleic acid sequence encoding an amino acid sequence having at least 90% identity to SEQ ID NO:
- 66.
A method of treating or preventing an infection by Chikungunya virus (CHIKV), the method comprising administering
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence having at least 90% identity to the nucleotide sequence that encodes SEQ ID NO:
- 65;
- or
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence encoding an amino acid sequence having at least 90% identity to SEQ ID NO:
- 66.
A method of treating or preventing an infection by Dengue virus (DENV), the method comprising administering
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 67;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 69;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 71;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 73;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 75;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence having at least 90% identity to a nucleotide sequence that encodes SEQ ID NO:
- 77;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence encoding amino acid sequence having at least 90% identity to SEQ ID NO:68;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence encoding amino acid sequence having at least 90% identity to SEQ ID NO:70;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence encoding amino acid sequence having at least 90% identity to SEQ ID NO:72;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence encoding amino acid sequence having at least 90% identity to SEQ ID NO:74;
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence encoding amino acid sequence having at least 90% identity to SEQ ID NO:76;
- or
- a nucleic acid molecule encoding a synthetic antibody comprising a nucleic acid sequence encoding amino acid sequence having at least 90% identity to SEQ ID NO:78.
Dependencies are inferred from the claim text.