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US 11,208,467 B2Granted
Peptides inhibiting KLK1, KLK4, or KLK4 and KLK8
AssigneeDaiichi Sankyo Company, Limited
InventorsDaisuke Nishimiya, Masakazu Tamura
Life of this patent
Estimating the term…
Abstract
A novel peptide which comprises an amino acid sequence represented by SEQ ID NO: 23, and specifically inhibits the protease activity of a target molecule.
Claims24
A serine protease inhibitor kazal-type 2 (SPINK2) mutant peptide which comprises an amino acid sequence represented by SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, or SEQ ID NO:
- 22.
7 more elements
A serine protease inhibitor kazal-type 2 (SPINK2) mutant peptide which comprises an amino acid sequence represented by SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, or SEQ ID NO:
- 22, and specifically inhibits protease activity of Kallikrein-related peptidase 4 (KLK4) and protease activity of Kallikrein-related peptidase 8 (KLK8).
7 more elements
A polynucleotide comprising a nucleotide sequence encoding the peptide sequence of SEQ ID NOs:
- 13-22.
Dependencies are inferred from the claim text.