Viral vector suitable for gene therapy encoding a variant of a BPIFB4 protein

A method for the treatment of a pathology or clinical condition, the method comprising administering to a subject in need of said treatment a therapeutic amount of a polynucleotide or of a vector containing a polynucleotide encoding a BPIFB4 protein variant consisting of the amino acid sequence of SEQ ID NO:

• 1, said vector containing said polynucleotide operatively linked to expression control sequences, wherein the activity of eNOS or the production of NO is increased and results in the amelioration or treatment of a pathology or clinical condition, wherein the pathology or clinical condition is selected from arterial hypertension, renal failure, erectile dysfunction, retinal degeneration, uveoretinitis, vascular retinopathy, glaucoma and pulmonary hypertension.