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US 11,207,407 B2Granted
Antibody formulations
AssigneeSanofi
InventorsDonny Francis, Ahmed Youssef, Stefaniya Korueva, Martina Kirsch
Life of this patent
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Abstract
High concentration antibody formulations capable of stable long-term storage are disclosed.
Claims12
An antibody formulation suitable for subcutaneous administration to a patient, the formulation comprising:
- a) about 100 to about 175 mg/mL of an antibody;
- b) about 10 mM citrate buffer;
- c) about 0.1% (w/v) surfactant;
- d) about 200 mM arginine;
- and
- e) about 4.5 to 9% sucrose,
- wherein the pH of the formulation is about pH 6, wherein the antibody is a fully human anti-CXCR5 antibody, and wherein the antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 33 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 32.
6 more elements
An antibody formulation, comprising:
- a) about 175 mg/mL of a humanized IgG4 anti-CXCR5 antibody;
- b) about 10 mM citrate buffer;
- c) about 1.0 mg/mL polysorbate 80;
- d) about 200 mM arginine HCl;
- and
- e) about 45 mg/mL sucrose,
- wherein the pH of the formulation is about pH 6, wherein the humanized IgG4 anti-CXCR5 antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 33 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 32.
6 more elements
Dependencies are inferred from the claim text.