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AssigneeMirimgene Co., Ltd.
InventorsSunghoon Kim, Mi Rim Jin, Young Ha Ahn
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The present invention relates to a composition for treatment or prevention of infectious inflammatory diseases comprising tryptophanyl-tRNA synthetase as an active ingredient, and a composition for immune enhancement. More specifically, the present invention relates to a pharmaceutical composition for treatment or prevention of infectious inflammatory diseasess comprising tryptophanyl-tRNA synthetase as an active ingredient, a food composition for preventing or improving, a veterinary composition for preventing or treating, and a composition for immune enhancement comprising a tryptophanyl-tRNA synthetase as an active ingredient, respectively. The composition of the present invention can be effectively used for preventing or treating diseases of humans and animals caused by infection from bacteria, viruses or fungi and the like by inhibiting infections such as bacterial, viral, and fungal infections at an early stage particularly through activating innate immune response.
A method for ameliorating or treating an infectious inflammatory disease caused by a bacterium, viruses or fungi in a subject in need thereof, the method comprising administering to the subject in need thereof a composition comprising a tryptophanyl-tRNA synthetase selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, and SEQ ID NO:8 as an active ingredient in an amount effective for ameliorating or treating an infectious inflammatory disease caused by a bacterium, viruses or fungi, wherein the tryptophanyl-tRNA synthetase increases infiltration of neutrophils in the subject.
A method for immune enhancement in a subject in need thereof, the method comprising administering to the subject in need thereof a composition comprising a tryptophanyl-tRNA synthetase selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, and SEQ ID NO:8 as an active ingredient in an amount effective for immune enhancement, wherein the tryptophanyl-tRNA synthetase increases infiltration of neutrophils in the subject.
Dependencies are inferred from the claim text.