Lantibiotics, lantibiotic-producing bacteria, compositions and methods of production and use thereof
AssigneeMemorial Sloan Kettering Cancer Center
InventorsEric Pamer, Sohn Kim, Peter McKenney, Silvia Caballero
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Abstract
The present disclosure relates to novel lantibiotics, lantibiotic pharmaceutical compositions, isolated and recombinant lantibiotic-producing bacteria, bacterial pharmaceutical compositions, methods of producing novel lantibiotics from lantibiotic-producing bacteria, and methods of using such lantibiotics, lantibiotic pharmaceutical compositions, and bacterial pharmaceutical compositions to treat gram-positive bacteria infections, including vancomycin resistant enterococci infections, in patients, and to treat food and other objects to avoid gram-positive bacteria contamination.
Claims20
A pharmaceutical composition comprising an isolated lantibiotic comprising a domain having the amino acid sequence of SEQ ID NO:
- 3 and a pharmaceutically acceptable carrier, wherein the domain comprises a thioether cross-link between:
- DHA3 and ALA7;
- DHB8 and ALA11;
- DHB13 and ALA19, DHB23 and ALA26;
- DHB25 and ALA28;
- or a combination thereof.
A method of treating a gram-positive bacteria colonization or infection, the method comprising administering to a patient in need of such treatment, a therapeutically effective amount of a composition comprising an isolated lantibiotic comprising a domain having the amino acid sequence of SEQ ID NO:
- 3, wherein the domain comprises a thioether cross-link between:
- DHA3 and ALA7;
- DHB8 and ALA11;
- DHB13 and ALA19, DHB23 and ALA26;
- DHB25 and ALA28;
- or a combination thereof.
A bacterial pharmaceutical composition comprising:
- (a) recombinant bacteria comprising an exogenous nucleic acid comprising the sequence of SEQ ID NO:
- 5 and operable to produce a lantibiotic having the sequence of SEQ ID NO:
- 3;
- and
- (b) a pharmaceutically acceptable carrier,
- wherein the recombinant bacteria is a bacteria that does not comprise an endogenous Lan A gene comprising the sequence of SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.