Back to results
US 11,203,596 B2Granted
Analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid and uses thereof for treating diseases and disorders associated with ornithine aminotransferase activity
AssigneeNorthwestern University
InventorsRichard B. Silverman, Matthew J. Moschitto
Life of this patent
Estimating the term…
Abstract
Disclosed are compound and methods of using the compounds for modulating ornithine aminotransferase (OAT) activity. The disclosed compound are characterized as analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid which may be formulated as therapeutic agents for treating diseases and disorders associated with ornithine aminotransferase (OAT) activity such as hepatocellular carcinoma and other cancers.
Claims20
A compound having the following formula or a dissociated form, protonated form, or salt thereof:
- wherein
- R1 is hydrogen, alkyl, or haloalkyl;
- and
- R2 is carboxyl, carboxylalkyl ester optionally substituted at one or more positions with halo, carboxylaryl ester, carboxylalkylaryl ester, carboxyl amide, carboxyl-N-alkyl amide, hydroxylalkyl, aminoalkyl, acyl, or cyano.
1 more element
A compound having a formula
- wherein
- PG is an amino-protecting group;
- R1 is hydrogen, alkyl, or haloalkyl;
- and
- R2 is carboxyl, carboxylalkyl ester optionally substituted at one or more positions with halo, carboxylaryl ester, carboxylalkylaryl ester, carboxyl amide, carboxyl-N-alkyl amide, hydroxylalkyl, aminoalkyl, acyl, or cyano.
2 more elements
Dependencies are inferred from the claim text.