US 11,203,569 B2Granted

Crystal forms of amino lipids

AssigneeModernaTX, Inc.

InventorsOrn Almarsson, Eugene Cheung

Life of this patent

Estimating the term…

Abstract

Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate (“Compound 1”), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (“Compound 2”), (3) heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate (“Compound 3”), and (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (“MC3”), and related compositions and methods.

Claims20

Dependent claims

A salt or cocrystal of heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (“Compound 2”).

Dependencies are inferred from the claim text.

Facts

Application: 16/493,789Filed 15 Mar 2018 · us provisional application
Priority: 15 Mar 2017
Published: US 2020/0131116 A130 Apr 2020
Granted: 21 Dec 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07C 229/12
The nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic…
C07C 55/07
Oxalic acid: salts thereof
C07C 65/03
Containing hydroxy or O-metal groups: monocyclic and having all hydroxy or O-metal groups bound to the ring
C07C 227/16
From compounds containing already amino and carboxyl groups or derivatives thereof: by reactions not involving the amino or carboxyl groups

Family

Application62/471,908Us provisional application · filed 15 Mar 2017
US 2020/0131116 A1Pre-grant publication · published 30 Apr 2020
US 11,203,569 B2This patent

From the US filing history. Foreign family members aren’t listed.

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