Porogen compositions, methods of making and uses
AssigneeAllergan, Inc.
InventorsFutian Liu, Nicholas J Manesis, Xiaojie Yu, Athene W. Chan
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Abstract
The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
Claims19
An uncured elastomer/porogen mixture comprising an elastomer and a porogen composition for coating a biocompatible implantable device comprising a porous material formed using the porogen composition, the porogen composition comprising a core material and a shell material, wherein the shell material comprises about 40% to 50% polyethylene glycol, by weight, wherein the core material comprises about 35% to about 50% sucrose and about 10% to about 15% starch, by weight, wherein the shell material has a melting temperature that is lower than a melting temperature of the core material, and wherein the shell material is adjacent to the core material.
An uncured elastomer/porogen mixture comprising an elastomer and a porogen composition for coating a biocompatible implantable device comprising a porous material formed using the porogen composition, the porogen composition comprises a mean porogen diameter of between about 1500 μm and about 3000 μm and a mean roundness of at least 0.1, the porogen composition comprising a core material and a shell material, wherein the core material comprises at least two compounds, wherein under a given physical or physicochemical treatment the shell material transitions from a solid phase to a liquid phase and the core material remains in a solid phase, and wherein the shell material is adjacent to the core material.
A biocompatible implantable device formed by a process comprising:
- applying an uncured elastomer/porogen mixture to form a layer of the device, the layer comprising an elastomer and a porogen composition;
- transitioning the layer from a solid phase to a liquid phase under a given physical or physiochemical treatment to fuse porogens of the porogen composition together to form a porogen scaffold;
- and
- removing the porogen scaffold from the layer under a given physical or physicochemical treatment.
Dependencies are inferred from the claim text.