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US 11,202,841 B2Granted
Virus-enabled targeted vector for imaging
AssigneeThe Trustees of Indiana University
InventorBogdan Dragnea
Life of this patent
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Abstract
A multi-chromophore virus particle is constructed by covalent binding of chromophores and provides super-radiant behavior. A virus-enabled targeted vector is provided for imaging with qualitatively different optical emission properties from state-of-the-art agents. Bright emission is obtained through quantum coherence, which in turn is facilitated by the symmetry of the virus shell. In an exemplary embodiment the targeted vector is used in laser-guided surgery, specifically for the treatment of in brain cancer.
Claims18
A method of forming a collection of virus-like particles (VLPs), the method comprising:
- obtaining virus capsids having surface-reactive groups;
- and
- chemically conjugating an array of N chromophores with the surface-reactive groups of each capsid, the N chromophores per capsid being sufficient to achieve collective behavior for the collection of VLPs, resulting in suppression of fluorescence quenching and collective spontaneous emission by the VLPs.
Dependencies are inferred from the claim text.