5-substituted 2,4-thiazolidinediones (thiohydantoins), pseudothiohydantoins, and propseudothiohydantoins for use as antiviral agents
AssigneeJiva Pharma, Inc.
InventorOm P Goel
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Abstract
The present invention concerns the synthesis and use of formulations of 5-substituted 2, 4-thiazolidinediones, pseudothiohydantoins, and propseudothiohydantoins and 2, 4-thiazolidinediones metforminate salts for topical and systemic treatments of infections caused by herpes simplex viruses and varicella zoster viruses.
Claims13
A method of treating persons who have viral infections comprising administering to such persons having infections from herpes simplex viruses (HSV1 or HSV2) or varicella zoster virus (VZV) a therapeutically effective amount of an antiviral agent as a pharmaceutically-acceptable formulation having as an active ingredient a compound of Formula (II) of the formula:
- wherein:
- R and R1 are each independently H;
- F;
- Cl;
- CH3;
- CF3;
- C1-C6 straight-chain or branched alkyls;
- C6-C10 aryl unsubstituted or substituted with fluoro or chloro;
- and
- when R is H, and R1 is a group as defined above other than H, then both R- and S-stereoisomers are included;
- or pharmaceutically-acceptable water soluble salts thereof.
Dependencies are inferred from the claim text.