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US 11,198,671 B2Granted
One-pot organo-pseudocatalytic C—H activation approach for the preparation of vortioxetine and vortioxetine intermediate
AssigneeVio AG Pharmaceuticals S.A.
InventorsTheocharis V. Koftis, Efstratios Neokosmidis, Thanos Andreou, Petros Gkizis, Alexandra Lithadioti
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Abstract
The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C—H activation approach via hypervalent iodine chemistry.
Claims7
A process for the preparation of compound of formula I, comprising subjecting compound of formula III, wherein R is hydrogen or o-aminothiophenolic radical, to reaction with compound of formula IV
A process for the preparation of compound of formula II, comprising the following steps:
- a) subjecting compound of formula III, wherein R is hydrogen or o-aminothiophenolic radical to reaction with compound of formula IV;
- b) converting compound of formula I into compound of formula II
Dependencies are inferred from the claim text.