Recombinant microorganism having enhanced ability to produce heme, coproporphyrin III, and uroporphyrin III, and method for producing heme, coproporphyrin III, and uroporphyrin III using same

A recombinant microorganism produced by transforming a host microorganism with at least one vector comprising a gene encoding a glutamyl-tRNA reductase (HemA), a gene encoding a glutamate-1-semialdehyde aminotransferase (HemL), and a gene encoding a diphtheria toxin repressor (DtxR),

• wherein the glutamyl-tRNA reductase (HemA) comprises the amino acid sequence of SEQ ID NO:
• 1,
• wherein the glutamate-1-semialdehyde aminotransferase (HemL) comprises the amino acid sequence of SEQ ID NO:
• 2,
• wherein the diphtheria toxin repressor (DtxR) comprises the amino acid sequence of SEQ ID NO:
• 3,
• wherein the host microorganism is Corynebacterium glutamicum,
• wherein the recombinant microorganism overexpresses the HemA, the HemL, and the DtxR as compared to a corresponding wild-type microorganism, and
• wherein the recombinant microorganism has improved capability to produce heme, coproporphyrin III, and uroporphyrin III as compared to a corresponding wild-type microorganism.