Aminopeptidase A inhibitors and pharmaceutical compositions comprising the same
AssigneesQuantum Genomics, Institut National de la Sante et de la Recherche Medicale, Centre National De La Recherche Scientifique, College De France
InventorsFabrice Balavoine, Delphine Compere, Catherine Llorens-Cortes, Yannick Marc
Life of this patent
Estimating the term…
Abstract
The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.
Claims13
A compound with the following formula (I):
- or formula (II):
- wherein
- AH represents —CO2H, —SO3H or —PO3H2;
- l is 1, 2 or 3;
- m and n are independently 0, 1 or 2;
- R3 and R4 represent independently a hydrogen atom, a hydroxy group, a halogen atom, an alkyl or a haloalkyl group;
- the ring (depicted by a circle in each formula) represents an aryl or a heterocycle;
- with R1 and R2 representing independently a hydrogen atom, a halogen atom, a cyano group, an alkyl group, an alkoxy group, an alkylthio group, an alkylsulfoxide group, an alkylsulfonyl group, a haloalkyl group, a haloalkoxy group, a haloalkylthio group, an acyl group, an O-cycloalkyl group, a heteroalkyl group, an O-aryl group, an O-arylalkyl group, an aryl group, a heterocycle group or an arylalkyl group;
- and
- a pharmaceutical salt, solvate, zwitterionic form or prodrug thereof.
Dependencies are inferred from the claim text.