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US 11,192,850 B2Granted
N-aryl oxamic acids
AssigneePurdue Research Foundation
InventorsZhong-Yin Zhang, Kasi Viswanatharaju Ruddraraju
Life of this patent
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Abstract
The present disclosure relates to novel N-aryl oxamic acid based inhibitors for Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB), and to the method of making and using the novel N-aryl oxamic acid based inhibitors. More specifically, compounds provided in this disclosure can be used to inhibit Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) and to treat a patient having a Tuberculosis disease.
Claims8
A compound of formula I:
- or a stereoisomer, tautomer, solvate, pharmaceutically acceptable salt thereof, wherein:
- (R1)n represents 1-3 independent R1 being attached to the phenyl ring wherein n is 1-3, wherein each of said 1-3 R1 independently represents a H, F, Cl, Br, I, —CN, —OR2, —COOR3, —NR4R5, —CO—R6, —SO2NR7R8, an optionally substituted C1-C5 branched or unbranched alkyl chain, an optionally substituted C3-C8 cyclic alkyl, an optionally substituted aryl, or an optionally substituted heteroaryl comprising one or more O, N, or S, or when n is 2, two independent R1 can join together to form a fused bicyclic ring with the phenyl ring;
- and
- R2-R8 each independently represents a H, an optionally substituted C1-C8 branched or unbranched alkyl chain, an optionally substituted C3-C8 cyclic alkyl, an optionally substituted aryl, or an optionally substituted heteroaryl comprising one or more O, N, or S, or a nitrogen protecting group.
1 more element
Dependencies are inferred from the claim text.