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US 11,191,865 B2Granted
Medical fibrous structure comprising calcium carboxymethyl cellulose and chitosan compound and process for preparing the same
AssigneeKorea Institute of Industrial Technology
InventorsJung Nam Im, Song Jun Doh, Tae Hee Kim, Yoonjin Kim, Chaehwa Kim, Gyu Dong Lee, Gahee Kim
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Abstract
Disclosed are a medical fiberous structure and a method for preparing the same, wherein the medical fiberous structure comprises calcium carboxymethyl cellulose and a chitosan compound, at least one of the calcium carboxymethyl cellulose and the chitosan compound having a fibrous shape.
Claims12
A medical fibrous structure comprising:
- calcium carboxymethyl cellulose fiber;
- and
- a chitosan compound fiber,
- wherein a weight ratio of the calcium carboxymethyl cellulose fiber and the chitosan compound fiber is from 70:30 to 30:70,
- wherein a calcium content in the calcium carboxymethyl cellulose fiber is 2 to 12 wt % per a total weight of the calcium carboxymethyl cellulose fiber,
- wherein the medical fibrous structure has absorbance of 0.30 or less as a blood coagulation property when measured at following conditions:
- dripping 100 μl of a mixed solution of blood and an anticoagulant that is sodium citrate of 3.8 w/v % at a volume ratio of 9:1 into the medical fibrous structure of dimensions 1 cm×1 cm,
- inducing coagulation in a 37° C. incubator for 10 minutes with an addition of 10 μl of 0.2M CaCl2 aqueous solution,
- eluting blood that does not participate in the coagulation of the blood in the mixed solution in 12.5 mL of distilled water,
- determining absorbance [AB] of 200 μl of the eluate at 540 nm wavelength, and absorbance [AW] of 200 μl of distilled water at 540 nm wavelength, and
- calculating the absorbance as the blood coagulation property by a following equation:
- the absorbance as the blood coagulation property=the absorbance of blood eluate [AB]−the absorbance of distilled water [AW].
9 more elements
A medical fibrous structure comprising:
- calcium carboxymethyl cellulose fiber and chitosan compound powder,
- wherein a weight ratio of the calcium carboxymethyl cellulose fiber and the chitosan compound power is from 70:30 to 30:70,
- wherein a calcium content in the calcium carboxymethyl cellulose fiber is 2 to 12 wt % per a total weight of the calcium carboxymethyl cellulose fiber,
- wherein the medical fibrous structure has absorbance of 0.30 or less as a blood coagulation property when measured at following conditions:
- dripping 100 μl of a mixed solution of blood and an anticoagulant that is sodium citrate of 3.8 w/v % at a volume ratio of 9:1 into the medical fibrous structure of dimensions 1 cm×1 cm;
- inducing coagulation in a 37° C. incubator for 10 minutes with an addition of 10 μl of 0.2M CaCl2 aqueous solution;
- eluting blood that does not participate in the coagulation of the blood in the mixed solution in 12.5 mL of distilled water;
- determining absorbance [AB] of 200 μl of the eluate at 540 nm wavelength, and absorbance [AW] of 200 μl of distilled water at 540 nm wavelength;
- and
- calculating the absorbance as the blood coagulation property by a following equation:
- the absorbance as the blood coagulation property=the absorbance of blood eluate [AB]−the absorbance of distilled water [AW].
8 more elements
Dependencies are inferred from the claim text.