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US 11,191,849 B2Granted
Compositions and methods for delivering messenger RNA
AssigneeArbutus Biopharma Corporation
InventorsMichael J. Abrams, James Heyes, Adam Judge, Kieu Mong Lam, Lorne Ralph Palmer, Stephen P. Reid, Edward D. Yaworski
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Abstract
The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease.
Claims10
A lipid nanoparticle comprising:
- (a) a cationic lipid;
- (b) a PEG-lipid conjugate present in an amount of at least 3 mole percent;
- and
- (c) mRNA encapsulated within the lipid nanoparticle;
- provided that the lipid nanoparticle comprises less than 0.5 mole percent phospholipid.
2 more elements
Dependencies are inferred from the claim text.