MHC class I associated hepatitis B peptides
AssigneeEmergex Vaccines Holding Ltd.
InventorRamila Philip
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Abstract
The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of Hepatitis B virus (HBV) infection, and discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a CTL response against HBV infection. The peptide and/or proteins of the invention may be used as a therapeutic drug to stimulate the immune system to recognize and eliminate HBV infection in infected cells or as a vaccine for the prevention of disease.
Claims4
A pharmaceutical composition comprising a polypeptide, oligopeptide or peptide consisting of 8 to about 30 amino acid residues and comprising a sequence that is (i) SEQ ID NO:
- 4 or (ii) an amino acid sequence that differs from SEQ ID NO:
- 4 by no more than one amino acid unit, wherein said amino acid difference is the addition or deletion of one amino acid to or from SEQ ID NO:4,
- wherein said polypeptide, oligopeptide or peptide binds to one or more class I WIC alleles or can be processed to bind to one or more class I WIC alleles and activate a T lymphocyte.
Dependencies are inferred from the claim text.