Polymyxin-based pharmaceutical composition for treating infectious diseases

A pharmaceutical composition with polymyxin and nephroprotectors, wherein the nephroprotectors are combinations of vitamins with a supramolecular combinatorial derivative of cyanocobalamin obtained by simultaneous acylation of the structure of cyanocobalamin with two different anhydrides and/or halogen anhydrides of monocarboxylic, dicarboxylic tricarboxylic and/or polycarboxylic acids;

• wherein a molar ratio of components of the combinatorial reaction is calculated according to the formulas:
• k=n×(2n−1) (1)
• and
• m=4×(3×2n-2−1) (2)
• where
• n=number of substitutional groups in cyanocobalamin;
• m=number of moles of the starting cyanocobalamin and a number of different molecules of its combinatorial derivatives after synthesis;
• and
• k=number of moles of each of two modifiers in the combinatorial synthesis reaction to obtain a maximum number of different derivatives.