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US 11,191,784 B2Granted
Methods and composition for gene delivery using an engineered viral particle
AssigneeThe Trustees of the University of Pennsylvania
InventorSaar Gill
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Abstract
The present invention provides compositions and methods for transducing cells (e.g. T cells or immune cells). Also provided herein are methods of treating a disease in a subject in need thereof.
Claims23
An engineered viral particle comprising:
- i. an engineered envelope comprising a polypeptide having the amino acid sequence of SEQ ID NO:
- 9;
- ii. a heterologous polypeptide targeting moiety for binding to a target cell;
- and
- iii. a nucleic acid molecule encoding a heterologous polypeptide of interest.
2 more elements
Dependencies are inferred from the claim text.