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US 11,191,768 B2Granted
Histone acetyltransferase activators and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsOttavio Arancio, Shixian Deng, Donald W. Landry, Jole Fiorito, Rosa Purgatorio, Owen Anthony O'Connor, Jennifer Effie Amengual
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Abstract
The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
Claims4
A compound of formula (I):
- or a pharmaceutically acceptable salt or solvate thereof,
- wherein R1a is OH;
- R3 is halogen or C1-C2-haloalkyl;
- and
- R4 is halogen or C1-C2-haloalkyl.
2 more elements
A compound having the structure:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.