Complement component iRNA compositions and methods of use thereof

A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of complement factor B (CFB) in a cell,

• wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region,
• wherein said sense strand comprises the nucleotide sequence of 5′-GCUGUGGUGUCUGAGUACUUU-3′ (SEQ ID NO:45), and said antisense strand comprises the nucleotide sequence of 5′ AAAGUACUCAGACACCACAGCCC-3′ (SEQ ID NO:76),
• wherein substantially all of the nucleotides of said sense strand comprise a modification selected from the group consisting of a 2′-O-methyl modification and a 2′-fluoro modification,
• wherein said sense strand comprises two phosphorothioate internucleotide linkages at the 5′-terminus,
• wherein substantially all of the nucleotides of said antisense strand comprise a modification selected from the group consisting of a 2′-O-methyl modification and a 2′-fluoro modification,
• wherein said antisense strand comprises two phosphorothioate internucleotide linkages at the 5′-terminus and two phosphorothioate internucleotide linkages at the 3′-terminus, and
• wherein said sense strand is conjugated to one or more GalNAc derivatives attached through a branched bivalent or trivalent linker at the 3′-terminus.