Increased production of ginsenosides through yeast cell organelle improvement
AssigneeKorea Research Institute of Chemical Technology
InventorsJu Young Lee, In Seung Jang, Seohyun Kim, Sun-Chang Kim, Suk Chea Jung, Jong Geon Jegal
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Abstract
Provided are a recombinant yeast having improved ability to produce ginsenoside, which is prepared by overexpressing INO2 and INO4 or deleting OPT1 in a yeast having ability to produce ginsenoside, a method of preparing the yeast, and a method of producing ginsenoside by using the yeast.
Claims2
A method of preparing ginsenoside or a precursor thereof, the method comprising the step of culturing a recombinant yeast for producing ginsenoside or a precursor thereof, wherein an expression level of a INO2 (INOsitol requiring 2) gene is increased, as compared with its intrinsic expression level, wherein the INO2 (INOsitol requiring 2) gene comprises the nucleotide sequence of SEQ ID NO:
- 1,
- and
- wherein the precursor is squalene, 2,3-oxidosqualene or protopanaxadiol.
Dependencies are inferred from the claim text.