Glucopyranosyl derivative and use thereof

A compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a pharmaceutically acceptable salt, a dimer, or a trimer thereof,

• wherein,
• L is —(CRaRb)q—, —CH═CH—(CRaRb)p—, —O—(CRaRb)p—, —NH—(CRaRb)p—, —S—(CRaRb)p—, —S(═O)—(CRaRb)p— or —S(═O)2—(CRaRb)p—;
• q is 1, 2, 3, 4, 5 or 6;
• p is 0, 1, 2, 3, 4, 5 or 6;
• each Ra and Rb is independently H, D, F, Cl, Br, I, CN, NO2, OH, NH2, —C(═O) OH, —SH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 haloalkoxy, C3-6 cycloalkyl or 3-6 membered heterocyclyl;
• or, Ra and Rb together with the carbon atom to which they are attached, form a C3-6 carbocycle or a 3-6 membered heterocycle;
• R1 is H, D, F, Cl, Br, I, OH, CN, NO2, NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkylamino, C1-6 alkylthio, C3-6 cycloalkyl or C3-6 cycloalkyl-C1-4 alkylene, wherein each of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkylamino, C1-6 alkylthio, C3-6 cycloalkyl and C3-6 cycloalkyl-C1-4 alkylene is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, OH, NH2, —C(═O) OH, —SH, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• each of R2 and R3 is independently H, D, CN, OH, NH2, —SH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, C3-6 cycloalkyl or 3-6 membered heterocyclyl, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, C3-6 cycloalkyl and 3-6 membered heterocyclyl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, OH, NH2, —C(═O) OH, —SH, ═O, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• or, R2 and R3 together with the carbon atom to which they are attached, form carbonyl,
• or, R2 and R3 together with the carbon atom to which they are attached, form a C3-6 carbocycle or a 3-6 membered heterocycle, wherein each of C3-6 carbocycle and 3-6 membered heterocycle is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, OH, NH2, —C(═O) OH, —SH, ═O, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• R4 is H, D, —OR4a or —SR4b;
• each of R4a and R4b is independently H, D, C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-4 alkylene, 5-6 membered heterocyclyl, (5-6 membered heterocyclyl)-C1-4 alkylene, C6-10 aryl, C6-10 aryl-C1-4 alkylene, 5-6 membered heteroaryl or (5-6 membered heteroaryl)-C1-4 alkylene, wherein each C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-4 alkylene, 5-6 membered heterocyclyl, (5-6 membered heterocyclyl)-C1-4 alkylene, C6-10 aryl, C6-10 aryl-C1-4 alkylene, 5-6 membered heteroaryl and (5-6 membered heteroaryl)-C1-4 alkylene is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, OH, NH2, —C(═O) OH, —SH, ═O, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• each R10 is independently H, D, F, Cl, Br, I, OH, CN, NO2, NH2, C1-6 alkyl or C1-6 alkoxy;
• R5 is H, D, C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, 3-8 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, wherein each of C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, 3-8 membered heterocyclyl, C6-10 aryl and 5-8 membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, OH, NH2, ═O, —C(═O) OH, —C(═O) NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 haloalkoxy, C3-6 cycloalkyl, 5-6 membered heterocyclyl, C6-10 aryl or 5-6 membered heteroaryl;
• each of R6 and R7 is independently H, D, F, Cl, Br, I, CN, NO2, OH, NH2, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 haloalkyl, C1-6 haloalkoxy, C3-8 cycloalkyl, 3-8 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, wherein each C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 haloalkyl, C1-6 haloalkoxy, C3-8 cycloalkyl, 3-8 membered heterocyclyl, C6-10 aryl and 5-8 membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, OH, NH2, ═O, —C(═O) OH, —C(═O) NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 haloalkoxy, C3-6 cycloalkyl, 5-6 membered heterocyclyl, C6-10 aryl or 5-6 membered heteroaryl;
• or, R6 and R7 together with the carbon atom to which they are attached, form a C3-8 carbocycle, a 3-8 membered heterocycle, a C6-10 aromatic ring or a 5-8 membered heteroaromatic ring, wherein each of C3-8 carbocycle, 3-8 membered heterocycle, C6-10 aromatic ring and 5-8 membered heteroaromatic ring is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, OH, NH2, ═O, —C(═O) OH, —C(═O) NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• or R5 and R6 together with the atom to which they are attached, or R5 and R7 together with the atom to which they are attached, form a 3-8 membered heterocycle or a 5-8 membered heteroaromatic ring, wherein each 3-8 membered heterocycle and 5-8 membered heteroaromatic ring is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, OH, NH2, ═O, —C(═O) OH, —C(═O) NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• each of R8 and R9 is independently H, D, ReO—C1-4 alkylene, RdRcN—C1-4 alkylene, C1-8 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, C3-8cycloalkyl-C1-4 alkylene, 3-8 membered heterocyclyl, (3-8 membered heterocyclyl) —C1-4 alkylene, C6-10 aryl, C6-10 aryl-C1-4 alkylene, 5-8 membered heteroaryl or (5-8 membered heteroaryl)-C1-4 alkylene, wherein each C1-8 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, C3-8cycloalkyl-C1-4 alkylene, 3-8 membered heterocyclyl, (3-8 membered heterocyclyl) —C1-4 alkylene, C6-10 aryl, C6-10 aryl-C1-4 alkylene, 5-8 membered heteroaryl and (5-8 membered heteroaryl)-C1-4 alkylene is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, ═O, —ORe, —NRcRd, —C(═O) ORe, —C(═O) NHRf, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• or, R8 and R9 together with the nitrogen atom to which they are attached, form a 3-8 membered heterocycle or a 5-8 membered heteroaromatic ring, wherein each of 3-8 membered heterocycle and 5-8 membered heteroaromatic ring is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, ═O, —ORe, —NRcRd, —C(═O)ORe, —C(═O)NHRf, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• each Rc, Rd, Re and Rf is independently H, D, C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, C3-8cycloalkyl-C1-4 alkylene, 3-8 membered heterocyclyl, (3-8 membered heterocyclyl) —C1-4 alkylene, C6-10 aryl, C6-10 aryl-C1-4 alkylene, 5-8 membered heteroaryl or (5-8 membered heteroaryl)-C1-4 alkylene, wherein each C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, C3-8cycloalkyl-C1-4 alkylene, 3-8 membered heterocyclyl, (3-8 membered heterocyclyl) —C1-4 alkylene, C6-10 aryl, C6-10 aryl-C1-4 alkylene, 5-8 membered heteroaryl and (5-8 membered heteroaryl)-C1-4 alkylene is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, OH, —NH2, ═O, —C(═O)OH, —C(═O)NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• or, Rc and Rd together with the nitrogen atom to which they are attached, form a 3-8 membered heterocycle or a 5-8 membered heteroaromatic ring, wherein each of 3-8 membered heterocycle and 5-8 membered heteroaromatic ring is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents, and the substituent is independently selected from D, F, Cl, Br, I, CN, NO2, ═O, OH, —NH2, —C(═O)OH, —C(═O)NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• n is 0, 1, 2 or 3;
• t is 0, 1, 2, 3, 4, 5 or 6;
• with the proviso that when R5 and R8 are both H, and R9 is
• t is not 0.