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US 11,185,601 B2Granted
Alpha(v)beta(6) integrin-binding peptides and methods of use thereof
AssigneeThe Regents of the University of California
InventorsYng Tang, Julie L. Sutcliffe
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Abstract
The present invention provides peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates comprise a moiety such as a PEG moiety, an imaging agent, or a therapeutic agent. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue. Compositions and kits containing the peptide conjugates of the present invention are also provided herein.
Claims35
A conjugate comprising:
- (a) a peptide that comprises the amino acid sequence VGDLTYLK (SEQ ID NO:1), wherein the peptide binds to an αvβ6 integrin, and
- (b) a moiety, wherein the moiety is selected from the group consisting of a polyethylene glycol (PEG) moiety, a fluorobenzoyl (FB) group, a methyl group, an acetyl group, an imaging agent, a therapeutic agent, and a combination thereof.
Dependencies are inferred from the claim text.