Pharmaceutical composition for preventing or treating ischemic-reperfusion injury comprising bile acids
AssigneeSamsung Life Public Welfare Foundation
InventorsHyeon Cheol Gwon, Hyung Suk Jang
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Abstract
The present invention relates to a composition for preventing, treating, or alleviating ischemia-reperfusion injury, containing bile acid. According to the present invention, bile acid increases intranuclear beta-catenin levels, interferes with the opening of a mitochondria permeable transition pore (mPTP), and has excellent effects, in ischemia-reperfusion injury animal models, of alleviating tissue injury and reducing the size of infarcts, thereby being usable in the prevention, treatment, or alleviation of ischemia-reperfusion injury.
Claims5
A method of preventing or treating myocardial ischemia-reperfusion injury, the method comprising:
- administering a bile acid or pharmaceutically acceptable salt thereof to a subject in need thereof, wherein the bile acid is at least one selected from the group consisting of deoxycholic acid and lithocholic acid.
Dependencies are inferred from the claim text.