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US 11,185,531 B2Granted
Arginine methyltransferase inhibitors and uses thereof
AssigneeEpizyme, Inc.
InventorsRichard Chesworth, Lorna Helen Mitchell, Gideon Shapiro
Life of this patent
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Abstract
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
Claims20
A compound of Formula (II):
- or a pharmaceutically acceptable salt thereof,
- wherein
- L1 is a bond;
- R3 is hydrogen, C1-4 alkyl, or C3-4 cycloalkyl;
- R4 is hydrogen or optionally substituted C1-6 alkyl;
- R5 is hydrogen or optionally substituted C1-4 alkyl;
- Rx is optionally substituted C1-4 alkyl or optionally substituted C3-4 cycloalkyl;
- and
- RW is optionally substituted carbocyclyl or optionally substituted heterocyclyl.
6 more elements
Dependencies are inferred from the claim text.