US 11,185,518 B2 · S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer

Abstract

Ketogenic compositions include a mixture of optically pure S-beta-hydroxybutyrate salts and acid(s) or non-racemic mixture of beta-hydroxybutyrate salts and acid(s) enriched with the S-enantiomer. The S-beta-hydroxybutyrate enantiomer modulates the effect of ketone bodies in the subject and controls the rate at which ketosis is achieved. Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for controlling ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contains from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.

Claims24

Dependent claims

A composition for administering ketone bodies and/or ketone body precursors to a subject, the composition comprising:

optically pure S-beta-hydroxybutyrate or a non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate enriched with S-beta-hydroxybutyrate so as to contain more than 50% and less than 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and less than 50% and more than 0% by enantiomeric equivalents of R-beta-hydroxybutyrate, with the proviso that:
when the composition comprises the optically pure S-beta-hydroxybutyrate it includes a mixture of at least one optically pure S-beta-hydroxybutyrate salt and optically pure S-beta-hydroxybutyric acid;
or
when the composition comprises the non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate it includes a mixture of:
at least two S-beta-hydroxybutyrate salts;
at least two R-beta-hydroxybutyrate salts;
and
at least one of S- or R-beta-hydroxybutyric acid.

5 more elements

A composition for administering ketone bodies and/or ketone body precursors to a subject, the composition comprising:

optically pure S-beta-hydroxybutyrate or a non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate enriched with S-beta-hydroxybutyrate so as to contain more than 50% and less than 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and less than 50% and more than 0% by enantiomeric equivalents of R-beta-hydroxybutyrate, with the proviso that:
when the composition comprises the optically pure S-beta-hydroxybutyrate it includes a mixture of at least one optically pure S-beta-hydroxybutyrate salt and optically pure S-beta-hydroxybutyric acid;
or
when the composition comprises the non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate it includes a mixture of:
at least one S-beta-hydroxybutyrate salt;
at least one R-beta-hydroxybutyrate salt;
and
at least one of S- or R-beta-hydroxybutyric acid,
wherein the composition is provided as or in a tablet, capsule, powder, food product, food additive, flavored beverage, vitamin fortified beverage, non-alcoholic beverage, flavored beverage additive, vitamin fortified beverage additive, non-alcoholic beverage additive, candy, sucker, pastille, food supplement, flavored mouth spray, or suppository.

6 more elements

Dependencies are inferred from the claim text.

S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer

Life of this patent

S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer

Life of this patent

Abstract

Claims24