Back to results
US 11,185,510 B2Granted
Combinations of mRNAs encoding immune modulating polypeptides and uses thereof
AssigneeModernaTX, Inc.
InventorsJoshua P. Frederick, Ailin Bai, Vladimir Presnyak, Stephen G. Hoge, Kerry Benenato, Iain McFadyen, Ellalahewage Sathyajith Kumarasinghe, Susannah Hewitt
Life of this patent
Estimating the term…
Abstract
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
Claims26
A lipid nanoparticle (LNP) comprising:
- (i) a first mRNA comprising an open reading frame (ORF) encoding a human IL-23 polypeptide and (ii) a second mRNA comprising an ORF encoding a human IL-36 gamma polypeptide, wherein the LNP comprises an ionizable amino lipid, a phospholipid, a sterol, and a PEG-modified lipid.
Dependencies are inferred from the claim text.